The Leona M. and Harry B. Helmsley Charitable Trust is a U.S.-based philanthropic foundation that provides strategic grant funding to advance healthcare, medical research, education, and community development. Rather than directly implementing projects, the Trust works through partnerships with universities, hospitals, research institutes, and nonprofit organizations to achieve impact. In the MENA region, it supports healthcare infrastructure, scientific innovation, and social services, and it also engages through regional partnerships, such as contributing to multi-donor health funds led by the Abu Dhabi Crown Prince Court to combat neglected tropical diseases in East Africa and Sudan. By channeling resources to trusted local and international partners, the Trust plays a catalytic role in improving health outcomes and strengthening institutions without serving as an on-the-ground operator itself.